Schizophrenia and dose adjustments
Tardive Dyskinesia TD : Risk of developing TD a syndrome of potentially irreversible, involuntary, dyskinetic movements and the likelihood it will become irreversible may increase with the duration of treatment and the cumulative dose. J Psychiatr Pract.
Schizophrenia treatment guidelines
Please also see the full Prescribing Information , including Boxed Warning. Monthly maintenance doses of paliperidone palmitate range from mg eq. Cerebrovascular Adverse Reactions, Including Stroke: In clinical trials with antipsychotic drugs, elderly subjects with dementia had a higher incidence of cerebrovascular adverse reactions, including fatalities vs placebo. Renal disease can play a large role in altering the pharmacokinetics of medications, especially in elimination or clearance and plasma protein binding. Mallikaarjun et al14 completed a small study evaluating the pharmacokinetics of aripiprazole in patients with renal impairment. Culpepper L. Dyslipidemia: Atypical antipsychotics cause adverse alterations in lipids have been observed in patients treated with atypical antipsychotics. Atypical antipsychotic metabolism and excretion. Pharmacokinetics of bupropion and its metabolites in haemodialysis patients who smoke.
If a drug is primarily excreted by the kidneys, elimination could be significantly altered, especially if the medication has active metabolites. Paxil [package insert]. Monitor weight at baseline and frequently thereafter. For patients with diseases, conditions, or medications that could exacerbate these effects, complete fall risk assessments when initiating antipsychotics and recurrently for patients on long-term therapy.
A rating scale for mania: reliability, validity and sensitivity.
The effect of serum lithium levels on renal function in geriatric outpatients: a retrospective longitudinal study.
based on 114 review